Search:
Browse
Collection All
bullet
bullet
bullet
bullet
Listed communities
bullet
bullet
bullet
bullet
bullet
bullet
bullet
bullet
bullet
bullet
bullet
bullet
bullet

Roehampton University Research Repository > School of Human and Life Sciences > Research papers from the School of Human & Life Sciences > Differential effect of streptozotocin-induced diabetes on the innervation of the ileum and distal colon.

Please use this identifier to cite or link to this item: http://hdl.handle.net/10142/92818
    Del.icio.us     LinkedIn     Citeulike     Connotea     Facebook     Stumble it!


SFX Query

Title: Differential effect of streptozotocin-induced diabetes on the innervation of the ileum and distal colon.
Authors: Belai, A.
Lincoln, J.
Milner, P.
Burnstock, G.
Citation: Differential effect of streptozotocin-induced diabetes on the innervation of the ileum and distal colon. 1991, 100 (4):1024-32 Gastroenterology
Journal: Gastroenterology
Issue Date: Apr-1991
URI: http://hdl.handle.net/10142/92818
PubMed ID: 2001799
Abstract: The effect of short-term and long-term streptozotocin-induced diabetes on the pattern of distribution and tissue content of adrenergic and peptidergic nerves in ileum and distal (descending) colon of the rat was examined using immunohistochemical, biochemical, and immunochemical techniques. The effect of short-term streptozotocin-induced diabetes on the level of noradrenaline compared with weight-restricted (starved) and untreated controls in the celiac (celiac-superior mesenteric ganglia complex) and inferior mesenteric ganglia, which supply the two regions of the intestine, was also compared. The pattern of change in the distribution of dopamine-beta-hydroxylase-, substance P-, calcitonin gene-related peptide-, and vasoactive intestinal polypeptide-like immunoreactive nerve fibres that was observed in the ileum from diabetic rats was not evident in the myenteric plexus of distal colon. In contrast to the ileum, there was no evidence of degenerative change in any of the nerve types investigated in the myenteric plexus of the distal colon. The level of vasoactive intestinal polypeptide in the diabetic rat ileum was significantly increased, whereas the level of noradrenaline was reduced; no such changes were observed in the distal colon. The tissue content of noradrenaline in the celiac ganglion, which projects to the ileum, was increased at 8-week diabetes compared with both weight-restricted and untreated controls, whereas the diabetic state had no effect on the levels of noradrenaline of the inferior mesenteric ganglion, which projects to the distal colon. It is concluded that there is a differential effect of streptozotocin-diabetes on different regions of the rat intestine. The adrenergic and peptidergic innervation of the distal colon were changed little compared with ileum. This may be explainable in terms of the different functional roles of these two regions of the intestine and/or by the difference in origin of the sympathetic nerves supplying the two regions of the intestine.
Type: Article
Language: en
MeSH: Animals
Colon
Diabetes Mellitus, Experimental
Ganglia, Sympathetic
Ileum
Male
Microscopy, Fluorescence
Norepinephrine
Peptides
Rats
Rats, Inbred Strains
Sympathetic Nervous System
Weight Loss
ISSN: 0016-5085
Appears in Collections: Research papers from the School of Human & Life Sciences

Files in This Item:

There are no files associated with this item.



Related articles on PubMed
bullet
Enteric nerves in diabetic rats: increase in vasoactive intestinal polypeptide but not substance P.
Belai A, Lincoln J, Milner P, Crowe R, Loesch A, Burnstock G
1985 Nov
bullet
bullet
bullet
bullet
See all 125 articles

All Items in RURR are protected by copyright, with all rights reserved, unless otherwise indicated.