Differential effect of immunosympathectomy on the expression of rat enteric neurotransmitters.

Hdl Handle:
http://hdl.handle.net/10142/92815
Title:
Differential effect of immunosympathectomy on the expression of rat enteric neurotransmitters.
Authors:
Belai, A.; Aberdeen, J.; Burnstock, G.
Abstract:
The effect of immunosympathectomy on the pattern of distribution of catecholamine- and peptide-containing nerve fibres and neurones in the myenteric and submucous plexuses of rat ileum was investigated. There was an increase in vasoactive intestinal polypeptide (VIP)-, galanin (GAL)- and substance P-like immunoreactivity in the myenteric plexus of ileum from rats treated with nerve growth factor (NGF) antiserum compared with controls. A similar increase in immunoreactivity was observed in VIP-, GAL- and neuropeptide Y (NPY)-containing submucous neurones and nerve fibres. In contrast, the immunosympathectomy had no effect on the pattern of distribution of catecholamine-, calcitonin gene-related peptide (CGRP)- and NPY-containing nerve fibres in the myenteric plexus or on substance P- and CGRP-containing neurones and nerve fibres of the submucous plexus. The findings of the present study suggest that NGF may differentially regulate the expression of enteric neuropeptides at a postnatal stage of development.
Citation:
Differential effect of immunosympathectomy on the expression of rat enteric neurotransmitters. 1992, 139 (2):157-60 Neurosci. Lett.
Journal:
Neuroscience letters
Issue Date:
25-May-1992
URI:
http://hdl.handle.net/10142/92815
PubMed ID:
1376876
Type:
Article
Language:
en
ISSN:
0304-3940
Appears in Collections:
Department of Life Sciences Collection

Full metadata record

DC FieldValue Language
dc.contributor.authorBelai, A.en
dc.contributor.authorAberdeen, J.en
dc.contributor.authorBurnstock, G.en
dc.date.accessioned2010-02-23T23:00:44Z-
dc.date.available2010-02-23T23:00:44Z-
dc.date.issued1992-05-25-
dc.identifier.citationDifferential effect of immunosympathectomy on the expression of rat enteric neurotransmitters. 1992, 139 (2):157-60 Neurosci. Lett.en
dc.identifier.issn0304-3940-
dc.identifier.pmid1376876-
dc.identifier.urihttp://hdl.handle.net/10142/92815-
dc.description.abstractThe effect of immunosympathectomy on the pattern of distribution of catecholamine- and peptide-containing nerve fibres and neurones in the myenteric and submucous plexuses of rat ileum was investigated. There was an increase in vasoactive intestinal polypeptide (VIP)-, galanin (GAL)- and substance P-like immunoreactivity in the myenteric plexus of ileum from rats treated with nerve growth factor (NGF) antiserum compared with controls. A similar increase in immunoreactivity was observed in VIP-, GAL- and neuropeptide Y (NPY)-containing submucous neurones and nerve fibres. In contrast, the immunosympathectomy had no effect on the pattern of distribution of catecholamine-, calcitonin gene-related peptide (CGRP)- and NPY-containing nerve fibres in the myenteric plexus or on substance P- and CGRP-containing neurones and nerve fibres of the submucous plexus. The findings of the present study suggest that NGF may differentially regulate the expression of enteric neuropeptides at a postnatal stage of development.en
dc.description.provenanceSubmitted by Abi Belai (a.belai@roehampton.ac.uk) on 2010-02-23T13:35:17Z No. of bitstreams: 0en
dc.description.provenanceApproved for entry into archive by Emily Selvidge(e.selvidge@roehampton.ac.uk) on 2010-02-23T23:00:44Z (GMT) No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2010-02-23T23:00:44Z (GMT). No. of bitstreams: 0 Previous issue date: 1992-05-25en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshAnimals, Newborn-
dc.subject.meshCatecholamines-
dc.subject.meshGalanin-
dc.subject.meshHistocytochemistry-
dc.subject.meshIleum-
dc.subject.meshNerve Fibers-
dc.subject.meshNerve Growth Factors-
dc.subject.meshNeurons-
dc.subject.meshNeuropeptides-
dc.subject.meshNeurotransmitter Agents-
dc.subject.meshPeptides-
dc.subject.meshPhenotype-
dc.subject.meshRats-
dc.subject.meshSubstance P-
dc.subject.meshSympathectomy-
dc.subject.meshVasoactive Intestinal Peptide-
dc.titleDifferential effect of immunosympathectomy on the expression of rat enteric neurotransmitters.en
dc.typeArticleen
dc.identifier.journalNeuroscience lettersen
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