Enhancement of A23187-induced release of enteric vasoactive intestinal polypeptide by phorbol 12,13-dibutyrate.

Hdl Handle:
http://hdl.handle.net/10142/92805
Title:
Enhancement of A23187-induced release of enteric vasoactive intestinal polypeptide by phorbol 12,13-dibutyrate.
Authors:
Belai, A.; Dale, M.M.; Burnstock, G.
Abstract:
The effect of phorbol 12,13-dibutyrate on calcium ionophore (A23187)-induced release of vasoactive intestinal polypeptide from enteric nerves was examined. A23187 caused release of vasoactive intestinal polypeptide dose dependently and phorbol 12,13-dibutyrate (100 nM) markedly shifted the dose-response curve of A23187 to the left. The significance of these findings will be discussed in relation to the mechanism of release of vasoactive intestinal polypeptide from enteric nerves.
Citation:
Enhancement of A23187-induced release of enteric vasoactive intestinal polypeptide by phorbol 12,13-dibutyrate. 1990, 177 (1-2):103-5 Eur. J. Pharmacol.
Journal:
European journal of pharmacology
Issue Date:
20-Feb-1990
URI:
http://hdl.handle.net/10142/92805
PubMed ID:
2111248
Type:
Article
Language:
en
ISSN:
0014-2999
Appears in Collections:
Department of Life Sciences Collection

Full metadata record

DC FieldValue Language
dc.contributor.authorBelai, A.en
dc.contributor.authorDale, M.M.en
dc.contributor.authorBurnstock, G.en
dc.date.accessioned2010-02-23T22:56:19Z-
dc.date.available2010-02-23T22:56:19Z-
dc.date.issued1990-02-20-
dc.identifier.citationEnhancement of A23187-induced release of enteric vasoactive intestinal polypeptide by phorbol 12,13-dibutyrate. 1990, 177 (1-2):103-5 Eur. J. Pharmacol.en
dc.identifier.issn0014-2999-
dc.identifier.pmid2111248-
dc.identifier.urihttp://hdl.handle.net/10142/92805-
dc.description.abstractThe effect of phorbol 12,13-dibutyrate on calcium ionophore (A23187)-induced release of vasoactive intestinal polypeptide from enteric nerves was examined. A23187 caused release of vasoactive intestinal polypeptide dose dependently and phorbol 12,13-dibutyrate (100 nM) markedly shifted the dose-response curve of A23187 to the left. The significance of these findings will be discussed in relation to the mechanism of release of vasoactive intestinal polypeptide from enteric nerves.en
dc.description.provenanceSubmitted by Abi Belai (a.belai@roehampton.ac.uk) on 2010-02-23T15:00:45Z No. of bitstreams: 0en
dc.description.provenanceApproved for entry into archive by Emily Selvidge(e.selvidge@roehampton.ac.uk) on 2010-02-23T22:56:19Z (GMT) No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2010-02-23T22:56:19Z (GMT). No. of bitstreams: 0 Previous issue date: 1990-02-20en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshCalcimycin-
dc.subject.meshEnzyme Activation-
dc.subject.meshIleum-
dc.subject.meshMale-
dc.subject.meshPhorbol 12,13-Dibutyrate-
dc.subject.meshProtein Kinase C-
dc.subject.meshRats-
dc.subject.meshRats, Inbred Strains-
dc.subject.meshVasoactive Intestinal Peptide-
dc.titleEnhancement of A23187-induced release of enteric vasoactive intestinal polypeptide by phorbol 12,13-dibutyrate.en
dc.typeArticleen
dc.identifier.journalEuropean journal of pharmacologyen
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