Changes in adrenergic and peptidergic nerves in the submucous plexus of streptozocin-diabetic rat ileum.

Hdl Handle:
http://hdl.handle.net/10142/92790
Title:
Changes in adrenergic and peptidergic nerves in the submucous plexus of streptozocin-diabetic rat ileum.
Authors:
Belai, A.; Burnstock, G.
Abstract:
The effect of streptozocin diabetes on the distribution of adrenergic and peptidergic nerves in the submucous plexus of rat ileum was investigated and compared with the changes in the myenteric plexus of the same region of ileum. There was an increase in the intensity of immunoreactivity in vasoactive intestinal polypeptide- and neuropeptide Y-like immunoreactive nerve fibers and neurons and a decrease in calcitonin gene-related peptide-like immunoreactivity but no change in substance P- and dopamine beta-hydroxylase-like immunoreactivity in the nerve fibers and neurons of the submucous plexus of both 8- and 16-wk streptozocin-diabetic rat ileum. However, in the myenteric plexus of the diabetic rat ileum, there was enlargement of varicosities and an increase followed by a slight decrease in the intensity of immunoreactivity of vasoactive intestinal polypeptide- and dopamine beta-hydroxylase-like immunoreactive nerve fibers and neurons, increased substance P-like immunoreactivity in diabetes at 16 wk, and an initial decrease (at 8 wk) followed by a recovery of calcitonin gene-related peptide-like immunoreactivity at 16 wk, but no change in neuropeptide Y-like immunoreactivity. The markedly different changes in peptidergic and adrenergic nerves between the two enteric plexuses show that diabetic neuropathy induced by streptozocin is not selective and involves factors other than neurotransmitter types.
Citation:
Changes in adrenergic and peptidergic nerves in the submucous plexus of streptozocin-diabetic rat ileum. 1990, 98 (6):1427-36 Gastroenterology
Journal:
Gastroenterology
Issue Date:
Jun-1990
URI:
http://hdl.handle.net/10142/92790
PubMed ID:
1692544
Type:
Article
Language:
en
ISSN:
0016-5085
Appears in Collections:
Department of Life Sciences Collection

Full metadata record

DC FieldValue Language
dc.contributor.authorBelai, A.en
dc.contributor.authorBurnstock, G.en
dc.date.accessioned2010-02-23T15:02:05Z-
dc.date.available2010-02-23T15:02:05Z-
dc.date.issued1990-06-
dc.identifier.citationChanges in adrenergic and peptidergic nerves in the submucous plexus of streptozocin-diabetic rat ileum. 1990, 98 (6):1427-36 Gastroenterologyen
dc.identifier.issn0016-5085-
dc.identifier.pmid1692544-
dc.identifier.urihttp://hdl.handle.net/10142/92790-
dc.description.abstractThe effect of streptozocin diabetes on the distribution of adrenergic and peptidergic nerves in the submucous plexus of rat ileum was investigated and compared with the changes in the myenteric plexus of the same region of ileum. There was an increase in the intensity of immunoreactivity in vasoactive intestinal polypeptide- and neuropeptide Y-like immunoreactive nerve fibers and neurons and a decrease in calcitonin gene-related peptide-like immunoreactivity but no change in substance P- and dopamine beta-hydroxylase-like immunoreactivity in the nerve fibers and neurons of the submucous plexus of both 8- and 16-wk streptozocin-diabetic rat ileum. However, in the myenteric plexus of the diabetic rat ileum, there was enlargement of varicosities and an increase followed by a slight decrease in the intensity of immunoreactivity of vasoactive intestinal polypeptide- and dopamine beta-hydroxylase-like immunoreactive nerve fibers and neurons, increased substance P-like immunoreactivity in diabetes at 16 wk, and an initial decrease (at 8 wk) followed by a recovery of calcitonin gene-related peptide-like immunoreactivity at 16 wk, but no change in neuropeptide Y-like immunoreactivity. The markedly different changes in peptidergic and adrenergic nerves between the two enteric plexuses show that diabetic neuropathy induced by streptozocin is not selective and involves factors other than neurotransmitter types.en
dc.description.provenanceSubmitted by Abi Belai (a.belai@roehampton.ac.uk) on 2010-02-23T15:00:09Z No. of bitstreams: 0en
dc.description.provenanceApproved for entry into archive by Emily Selvidge(e.selvidge@roehampton.ac.uk) on 2010-02-23T15:02:05Z (GMT) No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2010-02-23T15:02:05Z (GMT). No. of bitstreams: 0 Previous issue date: 1990-06en
dc.language.isoenen
dc.subject.meshAdrenergic Fibers-
dc.subject.meshAnimals-
dc.subject.meshCalcitonin Gene-Related Peptide-
dc.subject.meshDiabetes Mellitus, Experimental-
dc.subject.meshDopamine beta-Hydroxylase-
dc.subject.meshIleum-
dc.subject.meshImmunohistochemistry-
dc.subject.meshMale-
dc.subject.meshMyenteric Plexus-
dc.subject.meshNerve Fibers-
dc.subject.meshNeurons-
dc.subject.meshNeuropeptide Y-
dc.subject.meshRats-
dc.subject.meshRats, Inbred Strains-
dc.subject.meshStreptozocin-
dc.subject.meshSubmucous Plexus-
dc.subject.meshSubstance P-
dc.subject.meshVasoactive Intestinal Peptide-
dc.titleChanges in adrenergic and peptidergic nerves in the submucous plexus of streptozocin-diabetic rat ileum.en
dc.typeArticleen
dc.identifier.journalGastroenterologyen

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