Effects of long-term laxative treatment on neuropeptides in rat mesenteric vessels and caecum.

Hdl Handle:
http://hdl.handle.net/10142/92787
Title:
Effects of long-term laxative treatment on neuropeptides in rat mesenteric vessels and caecum.
Authors:
Milner, P.; Belai, A.; Tomlinson, A.; Hoyle, C.H.; Sarner, S.; Burnstock, G.
Abstract:
In order to investigate the toxic effects of long-term treatment with anthraquinone laxatives, rats were fed either chocolate alone, or chocolate adulterated with senna or danthron (1,8-dihydroxyanthraquinone) for 5 months. Mesenteric blood vessels and the outer muscle layers of the caecum, together with the myenteric plexus, were examined using ultrastructural, histochemical, immunohistochemical and immunoassay techniques. There was no ultrastructural evidence of degeneration in either the mesenteric vessels or the caecum. In the mesenteric vessels, levels of neuropeptide Y were significantly reduced in the danthron-fed rats, but levels of substance P (SP), calcitonin gene-related peptide (CGRP) and vasoactive intestinal polypeptide (VIP) were unaffected by all treatments. In the caecum, VIP-, SP- and CGRP-immunoreactivity and catecholamine-fluorescence were unchanged by the laxative treatments.
Citation:
Effects of long-term laxative treatment on neuropeptides in rat mesenteric vessels and caecum. 1992, 44 (9):777-9 J. Pharm. Pharmacol.
Journal:
The Journal of pharmacy and pharmacology
Issue Date:
Sep-1992
URI:
http://hdl.handle.net/10142/92787
PubMed ID:
1280681
Language:
en
ISSN:
0022-3573
Appears in Collections:
Department of Life Sciences Collection

Full metadata record

DC FieldValue Language
dc.contributor.authorMilner, P.en
dc.contributor.authorBelai, A.en
dc.contributor.authorTomlinson, A.en
dc.contributor.authorHoyle, C.H.en
dc.contributor.authorSarner, S.en
dc.contributor.authorBurnstock, G.en
dc.date.accessioned2010-02-23T14:58:34Z-
dc.date.available2010-02-23T14:58:34Z-
dc.date.issued1992-09-
dc.identifier.citationEffects of long-term laxative treatment on neuropeptides in rat mesenteric vessels and caecum. 1992, 44 (9):777-9 J. Pharm. Pharmacol.en
dc.identifier.issn0022-3573-
dc.identifier.pmid1280681-
dc.identifier.urihttp://hdl.handle.net/10142/92787-
dc.description.abstractIn order to investigate the toxic effects of long-term treatment with anthraquinone laxatives, rats were fed either chocolate alone, or chocolate adulterated with senna or danthron (1,8-dihydroxyanthraquinone) for 5 months. Mesenteric blood vessels and the outer muscle layers of the caecum, together with the myenteric plexus, were examined using ultrastructural, histochemical, immunohistochemical and immunoassay techniques. There was no ultrastructural evidence of degeneration in either the mesenteric vessels or the caecum. In the mesenteric vessels, levels of neuropeptide Y were significantly reduced in the danthron-fed rats, but levels of substance P (SP), calcitonin gene-related peptide (CGRP) and vasoactive intestinal polypeptide (VIP) were unaffected by all treatments. In the caecum, VIP-, SP- and CGRP-immunoreactivity and catecholamine-fluorescence were unchanged by the laxative treatments.en
dc.description.provenanceSubmitted by Abi Belai (a.belai@roehampton.ac.uk) on 2010-02-23T13:33:11Z No. of bitstreams: 0en
dc.description.provenanceApproved for entry into archive by Emily Selvidge(e.selvidge@roehampton.ac.uk) on 2010-02-23T14:58:34Z (GMT) No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2010-02-23T14:58:34Z (GMT). No. of bitstreams: 0 Previous issue date: 1992-09en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshAnthraquinones-
dc.subject.meshCacao-
dc.subject.meshCathartics-
dc.subject.meshCecum-
dc.subject.meshFemale-
dc.subject.meshImmunohistochemistry-
dc.subject.meshMesenteric Arteries-
dc.subject.meshMesenteric Veins-
dc.subject.meshMuscle, Smooth-
dc.subject.meshMuscle, Smooth, Vascular-
dc.subject.meshNeuropeptides-
dc.subject.meshRats-
dc.subject.meshRats, Sprague-Dawley-
dc.subject.meshSenna Extract-
dc.subject.meshSubstance P-
dc.subject.meshVasoactive Intestinal Peptide-
dc.titleEffects of long-term laxative treatment on neuropeptides in rat mesenteric vessels and caecum.en
dc.identifier.journalThe Journal of pharmacy and pharmacologyen

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