Prevention of neuropathy in the pyloric sphincter of streptozotocin-diabetic rats by gangliosides.

Hdl Handle:
http://hdl.handle.net/10142/92772
Title:
Prevention of neuropathy in the pyloric sphincter of streptozotocin-diabetic rats by gangliosides.
Authors:
Soediono, P.; Belai, A.; Burnstock, G.
Abstract:
BACKGROUND: The effect of diabetes on the density of peptide-containing nerves in the pyloric sphincter of streptozotocin-induced diabetic rats and the possible preventive action of the ganglioside mixture AGF1 on the diabetes-induced changes were investigated. METHODS: Immunohistochemical techniques were used to localize the general neuronal marker protein gene product 9.5 and the neuropeptides, calcitonin gene-related peptide, [met]-enkephalin, neuropeptide Y, substance P, and vasoactive intestinal polypeptide. RESULTS: The density of neurones showing immunoreactivity to the above peptides in nerves supplying the thickened circular muscle layer of the pyloric sphincter was reduced extensively in diabetic rats. In the ganglioside-treated diabetic animals, this reduction was prevented; indeed, calcitonin gene-related peptide- and substance P-like immunoreactivity in the ganglioside-treated diabetic rats exceeded that seen in control animals. In the ganglioside-treated controls, there was no significant difference in the peptide immunoreactivity from that of untreated controls. CONCLUSIONS: The results of the present study show that the ganglioside mixture AGF1 is effective in protecting the nerves of the pyloric sphincter from diabetes-induced changes.
Citation:
Prevention of neuropathy in the pyloric sphincter of streptozotocin-diabetic rats by gangliosides. 1993, 104 (4):1072-82 Gastroenterology
Journal:
Gastroenterology
Issue Date:
Apr-1993
URI:
http://hdl.handle.net/10142/92772
PubMed ID:
7681793
Language:
en
ISSN:
0016-5085
Appears in Collections:
Department of Life Sciences Collection

Full metadata record

DC FieldValue Language
dc.contributor.authorSoediono, P.en
dc.contributor.authorBelai, A.en
dc.contributor.authorBurnstock, G.en
dc.date.accessioned2010-02-23T13:29:32Z-
dc.date.available2010-02-23T13:29:32Z-
dc.date.issued1993-04-
dc.identifier.citationPrevention of neuropathy in the pyloric sphincter of streptozotocin-diabetic rats by gangliosides. 1993, 104 (4):1072-82 Gastroenterologyen
dc.identifier.issn0016-5085-
dc.identifier.pmid7681793-
dc.identifier.urihttp://hdl.handle.net/10142/92772-
dc.description.abstractBACKGROUND: The effect of diabetes on the density of peptide-containing nerves in the pyloric sphincter of streptozotocin-induced diabetic rats and the possible preventive action of the ganglioside mixture AGF1 on the diabetes-induced changes were investigated. METHODS: Immunohistochemical techniques were used to localize the general neuronal marker protein gene product 9.5 and the neuropeptides, calcitonin gene-related peptide, [met]-enkephalin, neuropeptide Y, substance P, and vasoactive intestinal polypeptide. RESULTS: The density of neurones showing immunoreactivity to the above peptides in nerves supplying the thickened circular muscle layer of the pyloric sphincter was reduced extensively in diabetic rats. In the ganglioside-treated diabetic animals, this reduction was prevented; indeed, calcitonin gene-related peptide- and substance P-like immunoreactivity in the ganglioside-treated diabetic rats exceeded that seen in control animals. In the ganglioside-treated controls, there was no significant difference in the peptide immunoreactivity from that of untreated controls. CONCLUSIONS: The results of the present study show that the ganglioside mixture AGF1 is effective in protecting the nerves of the pyloric sphincter from diabetes-induced changes.en
dc.description.provenanceSubmitted by Abi Belai (a.belai@roehampton.ac.uk) on 2010-02-23T13:28:49Z No. of bitstreams: 0en
dc.description.provenanceApproved for entry into archive by Emily Selvidge(e.selvidge@roehampton.ac.uk) on 2010-02-23T13:29:31Z (GMT) No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2010-02-23T13:29:32Z (GMT). No. of bitstreams: 0 Previous issue date: 1993-04en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshBiological Markers-
dc.subject.meshCalcitonin Gene-Related Peptide-
dc.subject.meshDiabetes Mellitus, Experimental-
dc.subject.meshDiabetic Neuropathies-
dc.subject.meshEnkephalin, Methionine-
dc.subject.meshFluorescent Antibody Technique-
dc.subject.meshGangliosides-
dc.subject.meshMale-
dc.subject.meshNeurons-
dc.subject.meshNeuropeptide Y-
dc.subject.meshPylorus-
dc.subject.meshRats-
dc.subject.meshRats, Wistar-
dc.subject.meshSubstance P-
dc.subject.meshThiolester Hydrolases-
dc.subject.meshUbiquitin Thiolesterase-
dc.subject.meshVasoactive Intestinal Peptide-
dc.titlePrevention of neuropathy in the pyloric sphincter of streptozotocin-diabetic rats by gangliosides.en
dc.identifier.journalGastroenterologyen
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