Effect of streptozotocin-diabetes on the level of VIP mRNA in myenteric neurones.

Hdl Handle:
http://hdl.handle.net/10142/92727
Title:
Effect of streptozotocin-diabetes on the level of VIP mRNA in myenteric neurones.
Authors:
Belai, A.; Facer, P.; Bishop, A.; Polak, J.M.; Burnstock, G.
Abstract:
The effect of streptozotocin-induced diabetes on the production of vasoactive intestinal polypeptide messenger RNA in the myenteric neurones of 8 weeks diabetic rat intestine was examined using in situ hybridization. Total ganglion cell number per length (mm) of tissue section was measured using NADH diaphorase histochemistry. Although ganglion cells were more numerous in the control preparations compared with diabetic samples, a significantly greater number of vasoactive intestinal polypeptide messenger RNA-containing cells was detected in the diabetic tissues. These observations suggest that there is either a decrease in the breakdown of vasoactive intestinal polypeptide messenger RNA or an increase in its synthesis in myenteric neurones of diabetic rat intestine.
Citation:
Effect of streptozotocin-diabetes on the level of VIP mRNA in myenteric neurones. 1993, 4 (3):291-4 Neuroreport
Journal:
Neuroreport
Issue Date:
Mar-1993
URI:
http://hdl.handle.net/10142/92727
PubMed ID:
8477051
Language:
en
ISSN:
0959-4965
Appears in Collections:
Department of Life Sciences Collection

Full metadata record

DC FieldValue Language
dc.contributor.authorBelai, A.en
dc.contributor.authorFacer, P.en
dc.contributor.authorBishop, A.en
dc.contributor.authorPolak, J.M.en
dc.contributor.authorBurnstock, G.en
dc.date.accessioned2010-02-23T13:30:10Z-
dc.date.available2010-02-23T13:30:10Z-
dc.date.issued1993-03-
dc.identifier.citationEffect of streptozotocin-diabetes on the level of VIP mRNA in myenteric neurones. 1993, 4 (3):291-4 Neuroreporten
dc.identifier.issn0959-4965-
dc.identifier.pmid8477051-
dc.identifier.urihttp://hdl.handle.net/10142/92727-
dc.description.abstractThe effect of streptozotocin-induced diabetes on the production of vasoactive intestinal polypeptide messenger RNA in the myenteric neurones of 8 weeks diabetic rat intestine was examined using in situ hybridization. Total ganglion cell number per length (mm) of tissue section was measured using NADH diaphorase histochemistry. Although ganglion cells were more numerous in the control preparations compared with diabetic samples, a significantly greater number of vasoactive intestinal polypeptide messenger RNA-containing cells was detected in the diabetic tissues. These observations suggest that there is either a decrease in the breakdown of vasoactive intestinal polypeptide messenger RNA or an increase in its synthesis in myenteric neurones of diabetic rat intestine.en
dc.description.provenanceSubmitted by Abi Belai (a.belai@roehampton.ac.uk) on 2010-02-23T13:29:32Z No. of bitstreams: 0en
dc.description.provenanceApproved for entry into archive by Emily Selvidge(e.selvidge@roehampton.ac.uk) on 2010-02-23T13:30:10Z (GMT) No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2010-02-23T13:30:10Z (GMT). No. of bitstreams: 0 Previous issue date: 1993-03en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshBody Weight-
dc.subject.meshDiabetes Mellitus, Experimental-
dc.subject.meshGanglia-
dc.subject.meshHistocytochemistry-
dc.subject.meshIn Situ Hybridization-
dc.subject.meshMale-
dc.subject.meshMyenteric Plexus-
dc.subject.meshNADPH Dehydrogenase-
dc.subject.meshNeurons-
dc.subject.meshProtein Biosynthesis-
dc.subject.meshRNA, Messenger-
dc.subject.meshRats-
dc.subject.meshRats, Wistar-
dc.subject.meshVasoactive Intestinal Peptide-
dc.titleEffect of streptozotocin-diabetes on the level of VIP mRNA in myenteric neurones.en
dc.identifier.journalNeuroreporten
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