The effects of hibernation on the myenteric plexus of the golden hamster small and large intestine.

Hdl Handle:
http://hdl.handle.net/10142/92721
Title:
The effects of hibernation on the myenteric plexus of the golden hamster small and large intestine.
Authors:
Toole, L.; Belai, A.; Shochina, M.; Burnstock, G.
Abstract:
We have examined the effects of hibernation on the neurochemical composition of myenteric neurones in the small and large intestine of the golden hamster using immunohistochemical and histochemical techniques. Hibernation was induced in golden hamsters by altering the photoperiod and external ambient temperature. Age-matched hamsters kept at room temperature and those kept at 5 degrees C but which failed to hibernate were used as controls. Cell counts were carried out to examine possible changes in the numbers of cell bodies immunoreactive to all of the markers examined. The results demonstrated a significant increase during hibernation in the number of neurones immunoreactive to vasoactive intestinal polypeptide, substance P and calcitonin gene-related peptide; cell bodies positive for tyrosine hydroxylase, which were largely absent in the control animals, were prominent in the hibernating animals. There was a significant decrease in the number of neurones immunoreactive to 5-hydroxytryptamine, and no significant changes in the numbers of neurones immunoreactive to protein gene-product and nitric oxide synthase. It is suggested that selective upregulation and downregulation of myenteric neurones containing certain neurotransmitters may occur as a protective mechanism during hibernation to maintain the integrity of the muscular and mucosal layers of the intestine in the absence of luminal contents.
Citation:
The effects of hibernation on the myenteric plexus of the golden hamster small and large intestine. 1999, 296 (3):479-87 Cell Tissue Res.
Journal:
Cell and tissue research
Issue Date:
Jun-1999
URI:
http://hdl.handle.net/10142/92721
PubMed ID:
10370134
Language:
en
ISSN:
0302-766X
Appears in Collections:
Department of Life Sciences Collection

Full metadata record

DC FieldValue Language
dc.contributor.authorToole, L.en
dc.contributor.authorBelai, A.en
dc.contributor.authorShochina, M.en
dc.contributor.authorBurnstock, G.en
dc.date.accessioned2010-02-23T13:21:49Z-
dc.date.available2010-02-23T13:21:49Z-
dc.date.issued1999-06-
dc.identifier.citationThe effects of hibernation on the myenteric plexus of the golden hamster small and large intestine. 1999, 296 (3):479-87 Cell Tissue Res.en
dc.identifier.issn0302-766X-
dc.identifier.pmid10370134-
dc.identifier.urihttp://hdl.handle.net/10142/92721-
dc.description.abstractWe have examined the effects of hibernation on the neurochemical composition of myenteric neurones in the small and large intestine of the golden hamster using immunohistochemical and histochemical techniques. Hibernation was induced in golden hamsters by altering the photoperiod and external ambient temperature. Age-matched hamsters kept at room temperature and those kept at 5 degrees C but which failed to hibernate were used as controls. Cell counts were carried out to examine possible changes in the numbers of cell bodies immunoreactive to all of the markers examined. The results demonstrated a significant increase during hibernation in the number of neurones immunoreactive to vasoactive intestinal polypeptide, substance P and calcitonin gene-related peptide; cell bodies positive for tyrosine hydroxylase, which were largely absent in the control animals, were prominent in the hibernating animals. There was a significant decrease in the number of neurones immunoreactive to 5-hydroxytryptamine, and no significant changes in the numbers of neurones immunoreactive to protein gene-product and nitric oxide synthase. It is suggested that selective upregulation and downregulation of myenteric neurones containing certain neurotransmitters may occur as a protective mechanism during hibernation to maintain the integrity of the muscular and mucosal layers of the intestine in the absence of luminal contents.en
dc.description.provenanceSubmitted by Abi Belai (a.belai@roehampton.ac.uk) on 2010-02-23T13:13:25Z No. of bitstreams: 0en
dc.description.provenanceApproved for entry into archive by Emily Selvidge(e.selvidge@roehampton.ac.uk) on 2010-02-23T13:21:49Z (GMT) No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2010-02-23T13:21:49Z (GMT). No. of bitstreams: 0 Previous issue date: 1999-06en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshCalcitonin Gene-Related Peptide-
dc.subject.meshCell Count-
dc.subject.meshCricetinae-
dc.subject.meshHibernation-
dc.subject.meshImmunohistochemistry-
dc.subject.meshIntestine, Large-
dc.subject.meshIntestine, Small-
dc.subject.meshMesocricetus-
dc.subject.meshMyenteric Plexus-
dc.subject.meshSubstance P-
dc.subject.meshVasoactive Intestinal Peptide-
dc.titleThe effects of hibernation on the myenteric plexus of the golden hamster small and large intestine.en
dc.identifier.journalCell and tissue researchen

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