Effects of streptozotocin-diabetes on sympathetic nerve, endothelial and smooth muscle function in the rat mesenteric arterial bed.

Hdl Handle:
http://hdl.handle.net/10142/92720
Title:
Effects of streptozotocin-diabetes on sympathetic nerve, endothelial and smooth muscle function in the rat mesenteric arterial bed.
Authors:
Ralevic, V.; Belai, A.; Burnstock, G.
Abstract:
Mesenteric arterial function was assessed in constantly perfused preparations isolated from rats 12 weeks after treatment with streptozotocin (65 mg kg-1, i.p.) to induce diabetes. Frequency-dependent vasoconstrictor responses to electrical field stimulation of sympathetic nerves (4-32 Hz, 0.1 ms, 90V, 30 s) were severely attenuated in preparations from streptozotocin-diabetic rats, although dose-dependent vasoconstrictions to the sympathetic cotransmitters noradrenaline and ATP, as well as to potassium chloride, were not significantly changed. Dose-dependent relaxations to the endothelium-dependent vasodilators acetylcholine and ATP were significantly impaired in preparations from streptozotocin-diabetic rats, although endothelium-independent vasodilatation to sodium nitroprusside was unimpaired. These results suggest 12 weeks after induction of streptozotocin-diabetes in rats there is pre-junctional impairment of sympathetic neurotransmission and impaired endothelial function of the mesenteric arteries. This is in contrast to our previous findings that at 8 weeks after induction of streptozotocin-diabetes sympathetic nerve and endothelial function is normal, although sensory-motor vasodilatation is severely attenuated. It is suggested that selective changes occur in mesenteric arterial function after streptozotocin treatment depending on the duration of diabetes; sensory-motor nerves are affected first, followed by sympathetic nerves and the endothelium, while the smooth muscle is relatively resistant to change.
Citation:
Effects of streptozotocin-diabetes on sympathetic nerve, endothelial and smooth muscle function in the rat mesenteric arterial bed. 1995, 286 (2):193-9 Eur. J. Pharmacol.
Journal:
European journal of pharmacology
Issue Date:
14-Nov-1995
URI:
http://hdl.handle.net/10142/92720
PubMed ID:
8605956
Language:
en
ISSN:
0014-2999
Appears in Collections:
Department of Life Sciences Collection

Full metadata record

DC FieldValue Language
dc.contributor.authorRalevic, V.en
dc.contributor.authorBelai, A.en
dc.contributor.authorBurnstock, G.en
dc.date.accessioned2010-02-23T13:21:08Z-
dc.date.available2010-02-23T13:21:08Z-
dc.date.issued1995-11-14-
dc.identifier.citationEffects of streptozotocin-diabetes on sympathetic nerve, endothelial and smooth muscle function in the rat mesenteric arterial bed. 1995, 286 (2):193-9 Eur. J. Pharmacol.en
dc.identifier.issn0014-2999-
dc.identifier.pmid8605956-
dc.identifier.urihttp://hdl.handle.net/10142/92720-
dc.description.abstractMesenteric arterial function was assessed in constantly perfused preparations isolated from rats 12 weeks after treatment with streptozotocin (65 mg kg-1, i.p.) to induce diabetes. Frequency-dependent vasoconstrictor responses to electrical field stimulation of sympathetic nerves (4-32 Hz, 0.1 ms, 90V, 30 s) were severely attenuated in preparations from streptozotocin-diabetic rats, although dose-dependent vasoconstrictions to the sympathetic cotransmitters noradrenaline and ATP, as well as to potassium chloride, were not significantly changed. Dose-dependent relaxations to the endothelium-dependent vasodilators acetylcholine and ATP were significantly impaired in preparations from streptozotocin-diabetic rats, although endothelium-independent vasodilatation to sodium nitroprusside was unimpaired. These results suggest 12 weeks after induction of streptozotocin-diabetes in rats there is pre-junctional impairment of sympathetic neurotransmission and impaired endothelial function of the mesenteric arteries. This is in contrast to our previous findings that at 8 weeks after induction of streptozotocin-diabetes sympathetic nerve and endothelial function is normal, although sensory-motor vasodilatation is severely attenuated. It is suggested that selective changes occur in mesenteric arterial function after streptozotocin treatment depending on the duration of diabetes; sensory-motor nerves are affected first, followed by sympathetic nerves and the endothelium, while the smooth muscle is relatively resistant to change.en
dc.description.provenanceSubmitted by Abi Belai (a.belai@roehampton.ac.uk) on 2010-02-23T13:20:03Z No. of bitstreams: 0en
dc.description.provenanceApproved for entry into archive by Emily Selvidge(e.selvidge@roehampton.ac.uk) on 2010-02-23T13:21:07Z (GMT) No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2010-02-23T13:21:08Z (GMT). No. of bitstreams: 0 Previous issue date: 1995-11-14en
dc.language.isoenen
dc.subject.meshAcetylcholine-
dc.subject.meshAnimals-
dc.subject.meshDiabetes Mellitus, Experimental-
dc.subject.meshEndothelium, Vascular-
dc.subject.meshMale-
dc.subject.meshMesenteric Arteries-
dc.subject.meshMuscle, Smooth, Vascular-
dc.subject.meshRats-
dc.subject.meshRats, Wistar-
dc.subject.meshStreptozocin-
dc.subject.meshSympathetic Nervous System-
dc.subject.meshVasoconstriction-
dc.titleEffects of streptozotocin-diabetes on sympathetic nerve, endothelial and smooth muscle function in the rat mesenteric arterial bed.en
dc.identifier.journalEuropean journal of pharmacologyen
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