Corticolimbic dysfunction during facial and prosodic emotional recognition in first-episode psychosis patients and individuals at ultra-high risk

Hdl Handle:
http://hdl.handle.net/10142/620167
Title:
Corticolimbic dysfunction during facial and prosodic emotional recognition in first-episode psychosis patients and individuals at ultra-high risk
Authors:
Tseng, Huai-Hsuan; Roiser, Jonathan P.; Modinos, Gemma; Falkenberg, Irina; Samson, Carly; McGuire, Philip; Allen, Paul ( 1 )
Abstract:
Emotional processing dysfunction is widely reported in patients with chronic schizophrenia and first-episode psychosis (FEP), and has been linked to functional abnormalities of corticolimbic regions. However, corticolimbic dysfunction is less studied in people at ultra-high risk for psychosis (UHR), particularly during processing prosodic voices. We examined corticolimbic response during an emotion recognition task in 18 UHR participants and compared them with 18 FEP patients and 21 healthy controls (HC). Emotional recognition accuracy and corticolimbic response were measured during functional magnetic resonance imaging (fMRI) using emotional dynamic facial and prosodic voice stimuli. Relative to HC, both UHR and FEP groups showed impaired overall emotion recognition accuracy. Whilst during face trials, both UHR and FEP groups did not show significant differences in brain activation relative to HC, during voice trials, FEP patients showed reduced activation across corticolimbic networks including the amygdala. UHR participants showed a trend for increased response in the caudate nucleus during the processing of emotionally valenced prosodic voices relative to HC. The results indicate that corticolimbic dysfunction seen in FEP patients is also present, albeit to a lesser extent, in an UHR cohort, and may represent a neural substrate for emotional processing difficulties prior to the onset of florid psychosis.
Affiliation:
Kings College London; National Cheng Kung University, Taiwan; University College London; Philipps-University Marburg; University of Roehampton
Citation:
Huai-Hsuan Tseng, Jonathan P. Roiser, Gemma Modinos, Irina Falkenberg, Carly Samson, Philip McGuire, Paul Allen, Corticolimbic dysfunction during facial and prosodic emotional recognition in first-episode psychosis patients and individuals at ultra-high risk, NeuroImage: Clinical, Available online 8 September 2016, ISSN 2213-1582, http://dx.doi.org/10.1016/j.nicl.2016.09.006.
Publisher:
Elsevier
Journal:
NeuroImage: Clinical
Issue Date:
8-Sep-2016
URI:
http://hdl.handle.net/10142/620167
DOI:
10.1016/j.nicl.2016.09.006
Additional Links:
http://www.sciencedirect.com/science/article/pii/S2213158216301644
Type:
Article
Language:
en
Description:
Accepted Date: 06/09/16; Version: Author Manuscript / Post-Print; Exceptions: None
ISSN:
2213-1582
Sponsors:
This work was supported by a Brain & Behavior Research Foundation NARSAD Independent Investigator Grant to PA, and a NARSAD Young Investigator Grant to GM (Lieber Investigator). IF was supported by the G.A. Lienert Foundation, Adolf-Schmidtmann-Foundation, FAZIT-Foundation and the German Academic Exchange Service. The funding agencies did not have any role in the design and conduct of the study; collection management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.
Appears in Collections:
Department of Psychology Collection

Full metadata record

DC FieldValue Language
dc.contributor.authorTseng, Huai-Hsuanen
dc.contributor.authorRoiser, Jonathan P.en
dc.contributor.authorModinos, Gemmaen
dc.contributor.authorFalkenberg, Irinaen
dc.contributor.authorSamson, Carlyen
dc.contributor.authorMcGuire, Philipen
dc.contributor.authorAllen, Paulen
dc.date.accessioned2016-09-15T15:39:59Z-
dc.date.available2016-09-15T15:39:59Z-
dc.date.issued2016-09-08-
dc.identifier.citationHuai-Hsuan Tseng, Jonathan P. Roiser, Gemma Modinos, Irina Falkenberg, Carly Samson, Philip McGuire, Paul Allen, Corticolimbic dysfunction during facial and prosodic emotional recognition in first-episode psychosis patients and individuals at ultra-high risk, NeuroImage: Clinical, Available online 8 September 2016, ISSN 2213-1582, http://dx.doi.org/10.1016/j.nicl.2016.09.006.en
dc.identifier.issn2213-1582-
dc.identifier.doi10.1016/j.nicl.2016.09.006-
dc.identifier.urihttp://hdl.handle.net/10142/620167-
dc.descriptionAccepted Date: 06/09/16; Version: Author Manuscript / Post-Print; Exceptions: Noneen
dc.description.abstractEmotional processing dysfunction is widely reported in patients with chronic schizophrenia and first-episode psychosis (FEP), and has been linked to functional abnormalities of corticolimbic regions. However, corticolimbic dysfunction is less studied in people at ultra-high risk for psychosis (UHR), particularly during processing prosodic voices. We examined corticolimbic response during an emotion recognition task in 18 UHR participants and compared them with 18 FEP patients and 21 healthy controls (HC). Emotional recognition accuracy and corticolimbic response were measured during functional magnetic resonance imaging (fMRI) using emotional dynamic facial and prosodic voice stimuli. Relative to HC, both UHR and FEP groups showed impaired overall emotion recognition accuracy. Whilst during face trials, both UHR and FEP groups did not show significant differences in brain activation relative to HC, during voice trials, FEP patients showed reduced activation across corticolimbic networks including the amygdala. UHR participants showed a trend for increased response in the caudate nucleus during the processing of emotionally valenced prosodic voices relative to HC. The results indicate that corticolimbic dysfunction seen in FEP patients is also present, albeit to a lesser extent, in an UHR cohort, and may represent a neural substrate for emotional processing difficulties prior to the onset of florid psychosis.en
dc.description.provenanceSubmitted by Camilla Griffiths (camilla.griffiths@roehampton.ac.uk) on 2016-09-15T12:41:12Z No. of bitstreams: 3 Corticolimbic dysfunction - neuroimage clinical 09-2016.pdf: 674211 bytes, checksum: b943766a91ecfd1711a4057b8abc27dc (MD5) license_text: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)en
dc.description.provenanceApproved for entry into archive by Camilla Griffiths (camilla.griffiths@roehampton.ac.uk) on 2016-09-15T15:39:59Z (GMT) No. of bitstreams: 3 Corticolimbic dysfunction - neuroimage clinical 09-2016.pdf: 674211 bytes, checksum: b943766a91ecfd1711a4057b8abc27dc (MD5) license_text: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)en
dc.description.provenanceMade available in DSpace on 2016-09-15T15:39:59Z (GMT). No. of bitstreams: 3 Corticolimbic dysfunction - neuroimage clinical 09-2016.pdf: 674211 bytes, checksum: b943766a91ecfd1711a4057b8abc27dc (MD5) license_text: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2016-09-08en
dc.description.sponsorshipThis work was supported by a Brain & Behavior Research Foundation NARSAD Independent Investigator Grant to PA, and a NARSAD Young Investigator Grant to GM (Lieber Investigator). IF was supported by the G.A. Lienert Foundation, Adolf-Schmidtmann-Foundation, FAZIT-Foundation and the German Academic Exchange Service. The funding agencies did not have any role in the design and conduct of the study; collection management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttp://www.sciencedirect.com/science/article/pii/S2213158216301644en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleCorticolimbic dysfunction during facial and prosodic emotional recognition in first-episode psychosis patients and individuals at ultra-high risken
dc.typeArticleen
dc.contributor.departmentKings College London; National Cheng Kung University, Taiwan; University College London; Philipps-University Marburg; University of Roehamptonen
dc.identifier.journalNeuroImage: Clinicalen
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