The optimal timing of stimulation to induce long-lasting positive effects on episodic memory in physiological aging

Hdl Handle:
http://hdl.handle.net/10142/610687
Title:
The optimal timing of stimulation to induce long-lasting positive effects on episodic memory in physiological aging
Authors:
Manenti, Rosa; Sandrini, Marco; Brambilla, Michela; Cotelli, Maria
Abstract:
Episodic memory displays the largest degree of age-related decline. A noninvasive brain stimulation technique that can be used to modulate memory in physiological aging is transcranial Direct Current Stimulation (tDCS). However, an aspect that has not been adequately investigated in previous studies is the optimal timing of stimulation to induce long-lasting positive effects on episodic memory function. Our previous studies showed episodic memory enhancement in older adults when anodal tDCS was applied over the left lateral prefrontal cortex during encoding or after memory consolidation with or without a contextual reminder. Here we directly compared the two studies to explore which of the tDCS protocols would induce longer-lasting positive effects on episodic memory function in older adults. In addition, we aimed to determine whether subjective memory complaints would be related to the changes in memory performance (forgetting) induced by tDCS, a relevant issue in aging research since individuals with subject memory complaints seem to be at higher risk of later memory decline. The results showed that anodal tDCS applied after consolidation with a contextual reminder induced longer-lasting positive effects on episodic memory, conceivably through reconsolidation, than anodal tDCS during encoding. Furthermore, we reported, providing new data, a moderate negative correlation between subjective memory complaints and forgetting when anodal tDCS was applied after consolidation with a contextual reminder. This study sheds light on the best-suited timing of stimulation to induce long-lasting positive effects on memory function and might help the clinicians to select the most effective tDCS protocol to prevent memory decline.
Affiliation:
University of Roehampton; Neuropsychology Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
Citation:
The optimal timing of stimulation to induce long-lasting positive effects on episodic memory in physiological aging 2016 Behavioural Brain Research
Publisher:
Elsevier
Journal:
Behavioural Brain Research
Issue Date:
May-2016
URI:
http://hdl.handle.net/10142/610687
DOI:
10.1016/j.bbr.2016.05.028
Additional Links:
http://linkinghub.elsevier.com/retrieve/pii/S0166432816303047
Type:
Article
Language:
en
Description:
Accepted Date: 12/05/2016; Published Date: 15/09/2016; Version: Author Manuscript / Post-Print; Exceptions: None. Made available here in accordance with the Creative Commons Attribution 4.0 International License.
ISSN:
01664328
Appears in Collections:
Department of Psychology Collection

Full metadata record

DC FieldValue Language
dc.contributor.authorManenti, Rosaen
dc.contributor.authorSandrini, Marcoen
dc.contributor.authorBrambilla, Michelaen
dc.contributor.authorCotelli, Mariaen
dc.date.accessioned2016-05-25T13:36:22Zen
dc.date.available2016-05-25T13:36:22Zen
dc.date.issued2016-05en
dc.identifier.citationThe optimal timing of stimulation to induce long-lasting positive effects on episodic memory in physiological aging 2016 Behavioural Brain Researchen
dc.identifier.issn01664328en
dc.identifier.doi10.1016/j.bbr.2016.05.028en
dc.identifier.urihttp://hdl.handle.net/10142/610687en
dc.descriptionAccepted Date: 12/05/2016; Published Date: 15/09/2016; Version: Author Manuscript / Post-Print; Exceptions: None. Made available here in accordance with the Creative Commons Attribution 4.0 International License.en
dc.description.abstractEpisodic memory displays the largest degree of age-related decline. A noninvasive brain stimulation technique that can be used to modulate memory in physiological aging is transcranial Direct Current Stimulation (tDCS). However, an aspect that has not been adequately investigated in previous studies is the optimal timing of stimulation to induce long-lasting positive effects on episodic memory function. Our previous studies showed episodic memory enhancement in older adults when anodal tDCS was applied over the left lateral prefrontal cortex during encoding or after memory consolidation with or without a contextual reminder. Here we directly compared the two studies to explore which of the tDCS protocols would induce longer-lasting positive effects on episodic memory function in older adults. In addition, we aimed to determine whether subjective memory complaints would be related to the changes in memory performance (forgetting) induced by tDCS, a relevant issue in aging research since individuals with subject memory complaints seem to be at higher risk of later memory decline. The results showed that anodal tDCS applied after consolidation with a contextual reminder induced longer-lasting positive effects on episodic memory, conceivably through reconsolidation, than anodal tDCS during encoding. Furthermore, we reported, providing new data, a moderate negative correlation between subjective memory complaints and forgetting when anodal tDCS was applied after consolidation with a contextual reminder. This study sheds light on the best-suited timing of stimulation to induce long-lasting positive effects on memory function and might help the clinicians to select the most effective tDCS protocol to prevent memory decline.en
dc.description.provenanceSubmitted by Anne Pietsch (a.pietsch@roehampton.ac.uk) on 2016-05-24T13:53:34Z No. of bitstreams: 3 sandrini_optimal_timing.pdf: 753981 bytes, checksum: 2094fff06e72bc75e9583e3b1858b17c (MD5) license_text: 22064 bytes, checksum: ef48816a10f2d45f2e2fee2f478e2faf (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)en
dc.description.provenanceApproved for entry into archive by Anne Pietsch (a.pietsch@roehampton.ac.uk) on 2016-05-25T13:36:21Z (GMT) No. of bitstreams: 3 sandrini_optimal_timing.pdf: 753981 bytes, checksum: 2094fff06e72bc75e9583e3b1858b17c (MD5) license_text: 22064 bytes, checksum: ef48816a10f2d45f2e2fee2f478e2faf (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)en
dc.description.provenanceMade available in DSpace on 2016-05-25T13:36:22Z (GMT). No. of bitstreams: 3 sandrini_optimal_timing.pdf: 753981 bytes, checksum: 2094fff06e72bc75e9583e3b1858b17c (MD5) license_text: 22064 bytes, checksum: ef48816a10f2d45f2e2fee2f478e2faf (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) Previous issue date: 2016-05en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0166432816303047en
dc.rightsArchived with thanks to Behavioural Brain Researchen
dc.titleThe optimal timing of stimulation to induce long-lasting positive effects on episodic memory in physiological agingen
dc.typeArticleen
dc.contributor.departmentUniversity of Roehampton; Neuropsychology Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italyen
dc.identifier.journalBehavioural Brain Researchen
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