A Molecular and Whole Body Insight of the Mechanisms Surrounding Glucose Disposal and Insulin Resistance with Hypoxic Treatment in Skeletal Muscle

Hdl Handle:
http://hdl.handle.net/10142/608460
Title:
A Molecular and Whole Body Insight of the Mechanisms Surrounding Glucose Disposal and Insulin Resistance with Hypoxic Treatment in Skeletal Muscle
Authors:
Mackenzie, R. W. A.; Watt, P.
Abstract:
Although the mechanisms are largely unidentified, the chronic or intermittent hypoxic patterns occurring with respiratory diseases, such as chronic pulmonary disease or obstructive sleep apnea (OSA) and obesity, are commonly associated with glucose intolerance. Indeed, hypoxia has been widely implicated in the development of insulin resistance either via the direct action on insulin receptor substrate (IRS) and protein kinase B (PKB/Akt) or indirectly through adipose tissue expansion and systemic inflammation. Yet hypoxia is also known to encourage glucose transport using insulin-dependent mechanisms, largely reliant on the metabolic master switch, 5′ AMP-activated protein kinase (AMPK). In addition, hypoxic exposure has been shown to improve glucose control in type 2 diabetics. The literature surrounding hypoxia-induced changes to glycemic control appears to be confusing and conflicting. How is it that the same stress can seemingly cause insulin resistance while increasing glucose uptake? There is little doubt that acute hypoxia increases glucose metabolism in skeletal muscle and does so using the same pathway as muscle contraction. The purpose of this review paper is to provide an insight into the mechanisms underpinning the observed effects and to open up discussions around the conflicting data surrounding hypoxia and glucose control.
Affiliation:
University of Roehampton; University of Brighton
Citation:
A Molecular and Whole Body Insight of the Mechanisms Surrounding Glucose Disposal and Insulin Resistance with Hypoxic Treatment in Skeletal Muscle 2016, 2016:1 Journal of Diabetes Research
Publisher:
Hindawi
Journal:
Journal of Diabetes Research
Issue Date:
12-Apr-2016
URI:
http://hdl.handle.net/10142/608460
DOI:
10.1155/2016/6934937
Additional Links:
http://www.hindawi.com/journals/jdr/2016/6934937/
Type:
Article
Language:
en
Description:
Accepted Date: 12/04/2016; Version: Author Manuscript / Post-Print; Exceptions: None
ISSN:
2314-6745; 2314-6753
Sponsors:
The authors would like to thank the Society for Endocrinology for its funding to support related research.
Appears in Collections:
Department of Life Sciences Collection

Full metadata record

DC FieldValue Language
dc.contributor.authorMackenzie, R. W. A.en
dc.contributor.authorWatt, P.en
dc.date.accessioned2016-05-06T08:49:14Zen
dc.date.available2016-05-06T08:49:14Zen
dc.date.issued2016-04-12en
dc.identifier.citationA Molecular and Whole Body Insight of the Mechanisms Surrounding Glucose Disposal and Insulin Resistance with Hypoxic Treatment in Skeletal Muscle 2016, 2016:1 Journal of Diabetes Researchen
dc.identifier.issn2314-6745en
dc.identifier.issn2314-6753en
dc.identifier.doi10.1155/2016/6934937en
dc.identifier.urihttp://hdl.handle.net/10142/608460en
dc.descriptionAccepted Date: 12/04/2016; Version: Author Manuscript / Post-Print; Exceptions: Noneen
dc.description.abstractAlthough the mechanisms are largely unidentified, the chronic or intermittent hypoxic patterns occurring with respiratory diseases, such as chronic pulmonary disease or obstructive sleep apnea (OSA) and obesity, are commonly associated with glucose intolerance. Indeed, hypoxia has been widely implicated in the development of insulin resistance either via the direct action on insulin receptor substrate (IRS) and protein kinase B (PKB/Akt) or indirectly through adipose tissue expansion and systemic inflammation. Yet hypoxia is also known to encourage glucose transport using insulin-dependent mechanisms, largely reliant on the metabolic master switch, 5′ AMP-activated protein kinase (AMPK). In addition, hypoxic exposure has been shown to improve glucose control in type 2 diabetics. The literature surrounding hypoxia-induced changes to glycemic control appears to be confusing and conflicting. How is it that the same stress can seemingly cause insulin resistance while increasing glucose uptake? There is little doubt that acute hypoxia increases glucose metabolism in skeletal muscle and does so using the same pathway as muscle contraction. The purpose of this review paper is to provide an insight into the mechanisms underpinning the observed effects and to open up discussions around the conflicting data surrounding hypoxia and glucose control.en
dc.description.provenanceSubmitted by Anne Pietsch (a.pietsch@roehampton.ac.uk) on 2016-05-06T08:48:08Z No. of bitstreams: 1 Mackenzie 2016.pdf: 1670674 bytes, checksum: 28b6a150ab706ad5832c329fd49a1d21 (MD5)en
dc.description.provenanceApproved for entry into archive by Anne Pietsch (a.pietsch@roehampton.ac.uk) on 2016-05-06T08:49:11Z (GMT) No. of bitstreams: 1 Mackenzie 2016.pdf: 1670674 bytes, checksum: 28b6a150ab706ad5832c329fd49a1d21 (MD5)en
dc.description.provenanceMade available in DSpace on 2016-05-06T08:49:14Z (GMT). No. of bitstreams: 1 Mackenzie 2016.pdf: 1670674 bytes, checksum: 28b6a150ab706ad5832c329fd49a1d21 (MD5) Previous issue date: 2016-04-12en
dc.description.sponsorshipThe authors would like to thank the Society for Endocrinology for its funding to support related research.en
dc.language.isoenen
dc.publisherHindawien
dc.relation.urlhttp://www.hindawi.com/journals/jdr/2016/6934937/en
dc.rightsArchived with thanks to Journal of Diabetes Researchen
dc.titleA Molecular and Whole Body Insight of the Mechanisms Surrounding Glucose Disposal and Insulin Resistance with Hypoxic Treatment in Skeletal Muscleen
dc.typeArticleen
dc.contributor.departmentUniversity of Roehampton; University of Brightonen
dc.identifier.journalJournal of Diabetes Researchen
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